HGH (human growth hormone) - The Truth About HGH Steroid
May 2, 2008
Effects of Human Growth Hormone
Human Growth Hormone (HGH) is a hormone that stimulates growth and cell reproduction in humans and other animals. It is a 191-amino acid, single chain polypeptide hormone which is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland. Somatotrophin refers to the growth hormone produced natively in animals, the term somatropin refers to growth hormone produced by recombinant DNA technology, and is abbreviated “rhGH”. Growth hormone has a variety of functions in the body, the most noticeable of which is the increase of height throughout childhood, and there are several diseases which can be treated through the therapeutic use of HGH.
HGH secretion
Several molecular isoforms of GH circulate in the plasma. Much of the growth hormone in the circulation is bound to a protein (growth hormone binding protein, GHBP) which is derived from the growth hormone receptor, and an acid label sub unit (ALS).
HGH side effects
There is theoretical concern that human growth hormone treatment may increase the risks of diabetes, especially in those with other predispositions treated with higher doses. One survey of adults who had been treated with replacement cadaver HGH (which has not been used anywhere in the world since 1985) during childhood showed a mildly increased incidence of colon cancer, but linkage with the HGH treatment was not established.
HGH therapeutic use
HGH can be used to treat conditions which produce short stature but are not related to deficiencies in growth hormone, though results are not as dramatic when compared to short stature solely due to deficiency of GH. Examples of other causes of shortness often treated with GH are Turner syndrome, chronic renal failure, Prader-Willi syndrome, intrauterine growth retardation, and severe idiopathic short stature. Higher (”pharmacologic”) doses are required to produce significant acceleration of growth in these conditions, producing blood levels well above physiologic. Despite the higher doses, side effects during treatment are rare, and vary little according to the condition being treated.
Human growth hormone treatment improves muscle strength and slightly reduces body fat in Prader-Willi syndrome, which are significant concerns beyond the need to increase height. HGH is also useful in maintaining muscle mass in wasting due to AIDS. HGH can also be used in patients with short bowel syndrome to lessen the requirement for intravenous total parenteral nutrition.
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